Focus on Molecules: Nuclear factor-kappaB
نویسندگان
چکیده
منابع مشابه
The nuclear factor-kappaB (NF-kappaB): from a versatile transcription factor to a ubiquitous therapeutic target.
The nuclear factor-kappaB (NF-kappaB) transcription factors regulate a plethora of cellular pathways and processes including the immune response, inflammation, proliferation, apoptosis and calcium homeostasis. In addition to the complexity of its physiological roles, the composition and function of this family of proteins is very complicated. While the basic understanding of NF-kappaB signallin...
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Heparanase (NP_001092010) is a heparin-binding endo-bD-glucuronidase expressed by normal lacrimal gland (GEO Profiles: GDS1361), corneal epithelia (Berk et al., 2004), retinal pigment epithelium/choroid, lens (NEIBank) and some non-ocular tissues. Heparanase is over-expressed in essentially all human tumors examined. Western blotting suggests that heparanase is a constituent of normal tears (Ma...
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Rootletin (accession number NP_742120) is a large coiled coil protein initially identified as a structural component of the ciliary rootlet (Yang et al., 2002). Its formal designation (ciliary rootlet coiled-coil, rootletin), as listed in most databases, reflects these two known aspects of the protein. The murine rootletin comprises 2009 amino acid residues and has a calculated molecular weight...
متن کاملFocus on molecules: sulfotyrosine.
Besides being a precursor for neurotransmitters, hormones and melanin, tyrosine is a non-essential amino acid that is utilized by the eukaryotic cell to synthesize proteins. Once incorporated into proteins, tyrosine can be post-translationally modified by virtue of its side chain hydroxyl group by nitration, phosphorylation and sulfation. While nitrotyrosine is synthesized through a nonenzymati...
متن کاملFocus on molecules: lacritin.
Lacritin is a 12.3 kDa secreted tear protein in human (accession Q9GZZ8 [Genpept; UniProt; Sanghi et al., 2001]) and non-human primates. It consists of 119 aa after removal of the signal peptide (SP; Fig. 1) and has a predicted isoelectric point (pI ) of 5. Predicted values for secreted lacritin in non-human primates include the following: 12.2 kDa and pI of 5 (Chlorocebus aethiops), 12.3 kDa a...
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ژورنال
عنوان ژورنال: Experimental Eye Research
سال: 2009
ISSN: 0014-4835
DOI: 10.1016/j.exer.2008.03.012